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However, derepression regarding ThPOK transcription inside the DP thymocytes from ThPOKCD4.Sil mice decorative mirrors term out of endogenous Cd4 inside DP thymocytes regarding wt rats. Eg, the new SilThPOK prevents this new transcription out-of Cd4 from inside the DP thymocytes out of CD4ThPOK.Sil mice just as the inhibition off endogenous ThPOK within the DP thymocytes off wt mice. FACS study away from TCR?, CD69, CD4, and you can CD8 term regarding (b) full thymocytes, gated thymocytes and you can (c) peripheral T-cellphone subsets out of wt rats or mutant lines, once the indicated. Mathematical value is actually determined for each and every indicated mutant line relative to wt mice. FACS research away from TCR?, CD69, CD4, and you will CD8 phrase regarding complete thymocytes, gated thymocytes (c), and peripheral T-cellphone subsets (d) off wt rats otherwise mutant lines, since the conveyed.
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